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RUNX1T1/RUNX1 Translocation by FISH

TEST DIRECTORY

Test Name

RUNX1T1/RUNX1 Translocation by FISH

Alternate Names

t(8;21), ETO/AML1

Description

Fluorescence in-situ hybridization (FISH) using a DNA probe set to detect rearrangements associated with acute myeloid leukemia, FAB type M2 (AML). This probe set also detects trisomy of chromosomes 8 and 21.

Test Code

40661

SPECIMEN REQUIREMENTS

Specimen Requirements

Fresh tissue collected in RPMI, bone marrow or peripheral blood collected in sodium heparin (green topped) tube

Supplies for Submission

Sodium heparin (green topped) tube

Storage Requirements

Store specimens at room temperature (15 to 30°C) until transported, adding a cold (refrigerator) pack during the summer months.

Causes for Rejections

Decalcified tissues are not accepted.

GENERAL AND TECHNICAL INFORMATION

Turn Around Time

Fresh tissue, bone marrow, and blood: 3-10 days

Methodology

Fluorescence in-situ hybridization (FISH)

CPT Code

Fresh tissue: 88271x2, 88275, 88291