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PML/RARα Translocation by FISH

TEST DIRECTORY

Test Name

PML/RARα Translocation by FISH

Alternate Names

t(15;17)

Description

Fluorescence in-situ hybridization (FISH) using a DNA probe set to identify the PML/RARα and variant translocations associated with AML FAB M3.

Test Code

51808

SPECIMEN REQUIREMENTS

Specimen

Bone marrow, neoplastic blood

Specimen Requirements

Bone marrow or peripheral blood collected in sodium heparin (green topped) tube

Storage Requirements

Store specimens at room temperature (15 to 30°C) until transported, adding a cold (refrigerator) pack during the summer months.

GENERAL AND TECHNICAL INFORMATION

Turn Around Time

Bone marrow and blood: 3-10 days

STAT preliminary result: 4-24 hours

Methodology

Fluorescence in-situ hybridization (FISH)

CPT Code

Fresh tissue: 88271x2, 88275, 88291