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Large Cell Lymphoma FISH Panel

TEST DIRECTORY

Test Name

Large Cell Lymphoma FISH Panel

Alternate Names

3q27, 8q24, 18q21

Description

Fluorescence in-situ hybridization (FISH) using DNA probes set to identify rearrangements and copy number changes. The panel consists of BCL6, MYC, MYC/IgH, and BCL2 (if positive reflex to IgH/BCL2).

Test Code

34618

SPECIMEN REQUIREMENTS

Specimen

Formalin-fixed paraffin embedded tissue, bone marrow, neoplastic blood

Specimen Requirements

Fresh tissue collected in RPMI, formalin-fixed paraffin embedded tissue, bone marrow or peripheral blood collected in sodium heparin (green topped) tube

Storage Requirements

Store specimens at room temperature (15 to 30°C) until transported, adding a cold (refrigerator) pack during the summer months.

Causes for Rejections

Decalcified tissues are not accepted.

GENERAL AND TECHNICAL INFORMATION

Turn Around Time

Formalin-fixed paraffin embedded tissue: 7 days

Fresh tissue, bone marrow, and blood: 3-10 days

Methodology

Fluorescence in-situ hybridization (FISH)

CPT Code

Formalin-fixed paraffin embedded tissue: 88377x4. If BCL2 is positive, reflex to IgH/BCL2: 88377x1.
Fresh tissue: 88271x8, 88275x4, 88291. If BCL2 is positive, reflex to IgH/BCl2: 88271x2, 88275.