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KMT2A Translocation/Deletion by FISH


TEST DIRECTORY
Test Name
KMT2A Translocation/Deletion by FISH
Alternate Names
MLL, 11q23
Description
Fluorescence in-situ hybridization (FISH) using a DNA probe set to detect rearrangements of the KMT2A gene associated with myeloid, lymphoid, or mixed lineage leukemia.
Test Code
89391
SPECIMEN REQUIREMENTS
Specimen
Bone marrow, neoplastic blood, tumor, effusion
Specimen Requirements
Formalin-fixed paraffin embedded tissue, bone marrow or peripheral blood collected in sodium heparin (green topped) tube
Storage Requirements
Store specimens at room temperature (15 to 30°C) until transported, adding a cold (refrigerator) pack during the summer months.
Causes for Rejections
Decalcified tissues are not accepted.
GENERAL AND TECHNICAL INFORMATION
Turn Around Time
Formalin-fixed paraffin embedded tissue: 7 days
Fresh tissue, bone marrow, and blood: 3-10 days
Methodology
Fluorescence in-situ hybridization (FISH)
CPT Code
  • Formalin-fixed paraffin embedded tissue: 88377
  • Fresh tissue: 88271x2, 88275, 88291