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RUNX1T1/RUNX1 Translocation by FISH


TEST DIRECTORY
Test Name
RUNX1T1/RUNX1 Translocation by FISH
Alternate Names
t(8;21), ETO/AML1
Description
Fluorescence in-situ hybridization (FISH) using a DNA probe set to detect rearrangements associated with acute myeloid leukemia, FAB type M2 (AML). This probe set also detects trisomy of chromosomes 8 and 21.
Test Code
40661
SPECIMEN REQUIREMENTS
Specimen Requirements
Fresh tissue collected in RPMI, formalin-fixed paraffin embedded tissue, bone marrow or peripheral blood collected in sodium heparin (green topped) tube
Supplies for Submission
Sodium heparin (green topped) tube
Storage Requirements
Store specimens at room temperature (15 to 30°C) until transported, adding a cold (refrigerator) pack during the summer months.
Causes for Rejections
Decalcified tissues are not accepted.
GENERAL AND TECHNICAL INFORMATION
Turn Around Time
Formalin-fixed paraffin embedded tissue: 7 days
Fresh tissue, bone marrow, and blood: 3-10 days
Methodology
Fluorescence in-situ hybridization (FISH)
CPT Code
  • Formalin-fixed paraffin embedded tissue: 88377x2
  • Fresh tissue: 88271x2, 88275, 88291