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ALK Rearrangement or Amplification by FISH


TEST DIRECTORY
Test Name
ALK Rearrangement or Amplification by FISH
Description
Fluorescence in-situ hybridization (FISH) using a DNA probe set to identify rearrangements or amplification of the ALK gene.
Test Code
91642
SPECIMEN REQUIREMENTS
Specimen
Formalin-fixed paraffin embedded tissue, bone marrow, neoplastic blood
Specimen Requirements
Fresh tissue collected in RPMI, formalin-fixed paraffin embedded tissue, bone marrow or peripheral blood collected in sodium heparin (green topped) tube
Storage Requirements
Store specimens at room temperature (15 to 30°C) until transport, adding a cold (refrigerator) pack during the summer months.
Causes for Rejections
Decalcified tissues are not accepted.
GENERAL AND TECHNICAL INFORMATION
Turn Around Time
Formalin-fixed paraffin embedded tissue: 7 days
Fresh tissue, bone marrow, and blood: 3-10 days
Methodology
Fluorescence in-situ hybridization (FISH)
CPT Code
  • Formalin-fixed paraffin embedded tissue: 88377
  • Fresh tissue: 88271x2, 88275, 88291