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CLL FISH Panel


TEST DIRECTORY
Test Name
CLL FISH Panel
Description
Fluorescence in-situ hybridization (FISH) using at least 7 DNA probe sets to detect rearrangements, deletions, and copy number changes associated with chronic lymphocytic leukemia/ small lymphocytic lymphoma, consisting of the following: MYB, ATM, 12, 13q14.3, IgH (if IgH+, reflex to CCND1/IgH and IgH/BCL2), TP53, BCL3.
Test Code
28279
SPECIMEN REQUIREMENTS
Specimen
Formalin-fixed paraffin embedded tissue, bone marrow, peripheral blood, tumor, effusion
Specimen Requirements
Formalin-fixed paraffin embedded tissue, bone marrow or peripheral blood collected in sodium heparin (green topped) tube
Storage Requirements
Store specimens at room temperature (15 to 30°C) until transported, adding a cold (refrigerator) pack during the summer months.
Causes for Rejections
Decalcified tissues are not accepted.
GENERAL AND TECHNICAL INFORMATION
Turn Around Time
Formalin-fixed paraffin embedded tissue: 7 days
Fresh tissue, bone marrow, and blood: 3-10 days
Methodology
Fluorescence in-situ hybridization (FISH)
CPT Code
  • Formalin-fixed paraffin embedded tissue: 88377x6. If IGH+, add 88377x2.
  • Fresh tissue: 88271x8, 88275x7, 88291. If IGH+, add 88271x4, 88275x2.